For those not interested in using escort cards to guide guests to their appropriate table you will need to use a seating chart.
Here are some great ones I found on Flickr:
These ones are broken down by tables:
For larger weddings it may be a necessity to alphabetize the guest list and break it down by last initial:
Whatever the design layout be creative. The seating chart will be one of the first things your guests see so why not have it match your theme or wedding colors!